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Things like GHRP3 can potently increase growth hormone, but are known to also potently increase prolactin and cortisol, leading to more than a doubling of circulating cortisol, which depending on how well regulated it is across the time of day can be problematic
Because TB-500 is often overexpressed in malignant cells and facilitates angiogenesis, there is a theoretical risk that it could accelerate the growth of dormant tumors or increase metastatic capacity in certain cancer phenotypes